Synthesis of 'Impossible' Rotaxanes.

'Impossible' rotaxanes, which are constituted by interlocked components without obvious binding motifs, have attracted the interest of the mechanically interlocked molecules (MIMs) community. Within the synthetic efforts reported in the last decades towards the preparation of MIMs, some innovative protocols for accessing 'impossible' rotaxanes have been developed. This short review highlights different selected synthetic examples of 'impossible' rotaxanes, as well as suggests some future directions of this research area.

A Comparative Study of Dogs and Goats with Limited Human Socialization in the Impossible Task Paradigm.

The study aimed to explore how limited human socialization affects the socio-cognitive abilities and interactions with unfamiliar individuals of a selected group of domesticated dogs and goats. These animals were raised and kept under conditions characterized by limited human socialization, and their behavior was assessed using the "impossible task" paradigm. The study found that dogs, with a history of cooperative interactions and human companionship, exhibited more frequent social engagement with human experimenters in the experimental setting than goats, traditionally domesticated for utilitarian purposes. However, differences in interaction duration and latency were not significant, highlighting the complexity of these interactions. The results suggest that domestication history and behavioral ecology play significant roles in shaping animals' willingness to engage with humans. However, this study acknowledges limitations, such as the specific population studied, and calls for further research with larger and more diverse samples to generalize these findings. Understanding the interplay between domestication history, behavioral ecology, and human socialization could provide insights into the complex factors influencing animal-human interactions and cognitive behaviors, with implications for animal welfare and human-animal relationships.

Home Sweet Home: The Impact of Lifestyle on a Cat's Approach to Impossible Tasks in the Home Environment.

Cat welfare is a topic of growing interest in the scientific literature. Although previous studies have focused on the effects of living style (i.e., indoor/outdoor) on cat welfare, there has been a noticeable dearth of analysis regarding the impact of lifestyle on cats' inclination and mode of communication with humans. Our research aimed to analyze the possible effect of lifestyle (e.g., living indoors only or indoor/outdoor) on cat-human communication. The cats were tested using the impossible task paradigm test, which consists of some solvable trials in which the subject learns to obtain a reward from an apparatus, followed by an impossible trial through blocking the apparatus. This procedure triggers a violation of expectations and is considered a useful tool for assessing both the decision-making process and the tendency to engage in social behaviors towards humans. A specific ethogram was followed to record the behavioral responses of the cats during the unsolvable trial. Our results show the effects of lifestyle and age on domestic cats, providing valuable insights into the factors that influence their social behaviors. Cats that can roam freely outdoors spent less time interacting with the apparatus compared to indoor-only cats. Additionally, roaming cats showed stress behaviors sooner following the expectancy of violation compared to indoor cats. The lifestyle of cats can influence their problem-solving approach while not affecting their willingness to interact with humans or their overall welfare. Future studies on this topic can be useful for improving the welfare of domestic cats.

Large languages, impossible languages and human brains.

We aim at offering a contribution to highlight the essential differences between Large Language Models (LLM) and the human language faculty. More explicitly, we claim that the existence of impossible languages for humans does not have any equivalent for LLM making them unsuitable models of the human language faculty, especially for a neurobiological point of view. The core part is preceded by two premises bearing on the distinction between machines and humans and the distinction between competence and performance.

Piaget's 3-mountains task with impossible options: Sighted, blindfolded, early and late blind participants.

In Piaget's 3-mountains task, 3D objects - a cube, cone and sphere - sit on a square tabletop. They are portrayed in 2D pictures as elevations (projections to the sides) such as one with a square on the left, a triangle in the middle and a circle on the right. Three objects offer six elevations, of which four are possible and two impossible. The possibles are elevations from the sides of the table - front, left, right and rear. In the impossibles, an object in the corner of the table is shown in the middle of an elevation. Sighted, sighted-blindfolded, early- and late-blind adults judged the elevations as to side of the table or impossible. The results suggest similar spatial abilities across groups. The impossible options had mid-range accuracy for all groups, with reaction times like possible options. The sighted and blind participants may consider possible and impossible options sequentially, one item at a time.

Difficult or impossible facemask ventilation in children with difficult tracheal intubation: a retrospective analysis of the PeDI registry.

BACKGROUND: Difficult facemask ventilation is perilous in children whose tracheas are difficult to intubate. We hypothesised that certain physical characteristics and anaesthetic factors are associated with difficult mask ventilation in paediatric patients who also had difficult tracheal intubation. METHODS: We queried a multicentre registry for children who experienced "difficult" or "impossible" facemask ventilation. Patient and case factors known before mask ventilation attempt were included for consideration in this regularised multivariable regression analysis. Incidence of complications, and frequency and efficacy of rescue placement of a supraglottic airway device were also tabulated. Changes in quality of mask ventilation after injection of a neuromuscular blocking agent were assessed. RESULTS: The incidence of difficult mask ventilation was 9% (483 of 5453 patients). Infants and patients having increased weight, being less than 5th percentile in weight for age, or having Treacher-Collins syndrome, glossoptosis, or limited mouth opening were more likely to have difficult mask ventilation. Anaesthetic induction using facemask and opioids was associated with decreased risk of difficult mask ventilation. The incidence of complications was significantly higher in patients with "difficult" mask ventilation than in patients without. Rescue placement of a supraglottic airway improved ventilation in 71% (96 of 135) of cases. Administration of neuromuscular blocking agents was more frequently associated with improvement or no change in quality of ventilation than with worsening. CONCLUSIONS: Certain abnormalities on physical examination should increase suspicion of possible difficult facemask ventilation. Rescue use of a supraglottic airway device in children with difficult or impossible mask ventilation should be strongly considered.

Serum Oxytocin, Cortisol and Social Behavior in Calves: A Study in the Impossible Task Paradigm.

In this study, we explored the correlations between circulating levels of oxytocin, cortisol, and different social behaviors toward humans in 26 Italian Red Pied calves (all females, with an average age of 174 ± 24 days) using the impossible task paradigm. This paradigm has proved fruitful in highlighting the effect of socialization on the willingness to interact with humans in several domesticated species. The test consists of the violation of an expectation (recovering food from an experimental apparatus) while a caregiver and a stranger are present. Immediately after the end of the test (less than one minute), blood was collected from the coccygeal vein. Statistics were performed by the Spearman's rank correlation; significant differences were adjusted according to Bonferroni's correction. Cortisol correlates positively (ρ = 0.565; p < 0.05) with the latency of behaviors directed at the caregiver, and the duration of behaviors directed at the apparatus correlates negatively with both the caregiver (ρ = -0.654; p < 0.05) and a stranger (ρ = -0.644; p < 0.05). Contrary to what is reported in the literature on cows, no correlations were found between oxytocin levels and direct behaviors toward the caregiver. This highlights a different behavioral strategy between calves and cows when placed in front of an impossible task.

Counterpossibles in science: an experimental study.

A counterpossible is a counterfactual whose antecedent is impossible. The vacuity thesis says all counterpossibles are true solely because their antecedents are impossible. Recently, some have rejected the vacuity thesis by citing purported non-vacuous counterpossibles in science. One limitation of this work, however, is that it is not grounded in experimental data. Do scientists actually reason non-vacuously about counterpossibles? If so, what is their basis for doing so? We presented biologists (N = 86) with two counterfactual formulations of a well-known model in biology, the antecedents of which contain what many philosophers would characterize as a metaphysical impossibility. Participants consistently judged one counterfactual to be true, the other to be false, and they explained that they formed these judgments based on what they perceived to be the mathematical relationship between the antecedent and consequent. Moreover, we found no relationship between participants' judgments about the (im)possibility of the antecedent and whether they judged a counterfactual to be true or false. These are the first experimental results on counterpossibles in science with which we are familiar. We present a modal semantics that can capture these judgments, and we deal with a host of potential objections that a defender of the vacuity thesis might make.

Experiencing the impossible and creativity: a targeted literature review.

Previous work suggests that unexpected and surprising experiences (e.g., living in another culture or looking at surreal images) promotes creative thinking. This targeted literature review examines whether the inherent cognitive disruption associated with experiencing the seemingly impossible has a similar effect. Correlational and experimental research across six domains (entertainment magic, fantasy play, virtual reality and computer gaming, dreaming, science fiction/fantasy, and anomalous experiences) provided consistent support for the hypothesis. In addition, anecdotal evidence illustrated the possible impact that the creative output associated with each of these areas may have had on technology, science, and the arts. It is argued that impossible experiences are an important driver of creative thinking, thus accounting for reports of such experiences across the lifespan and throughout history. The theoretical and practical implications of this work are discussed, along with recommendations for future research.

When is it impractical to ask informed consent? A systematic review.

BACKGROUND: Informed consent is one of the cornerstones of biomedical research with human subjects. Research ethics committees may allow for a modification or a waiver of consent when the research has social value, involves minimal risk, and if consent is impractical to obtain. While the conditions of social value and minimal risk have received ample attention in research ethics literature, the impractical condition remains unclear. There seem to be different interpretations of the meaning of impractical within academic literature. To address this lack of clarity, we performed a systematic review on the interpretation of impractical. METHODS: First, we examined international research ethics guidelines on their usage and interpretation of impractical. Next, we used international ethical guidelines to identify synonyms of the term "impractical." Accordingly, PubMed, Embase, and Web of Science were searched for articles that included "informed consent" and "impractical" or one of its synonyms. RESULTS: We found that there were only a few international ethics guidelines that described what could be considered impractical. Out of 2329 identified academic articles, 42 were included. Impractical was used to describe four different conditions: (1) obtaining informed consent becomes too demanding for researchers, (2) obtaining informed consent leads to invalid study outcomes, (3) obtaining informed consent harms the participant, and (4) obtaining informed consent is meaningless for the participant. CONCLUSION: There are conditions that render conventional informed consent truly impractical, such as untraceable participants or harm for participants. At the same time, researchers have a moral responsibility to design an infrastructure in which consent can be obtained, even if they face hardship in obtaining consent. In addition, researchers should seek to minimize harm inflicted upon participants when harm may occur as a result of the consent procedure. Invalidity of research due to consent issues should not be regarded as impractical but as a condition that limits the social value of research. Further research is essential for when a waiver of informed consent based on impractical is also reasonable.

A bit-vector differential model for the modular addition by a constant and its applications to differential and impossible-differential cryptanalysis.

ARX algorithms are a class of symmetric-key algorithms constructed by Addition, Rotation, and XOR. To evaluate the resistance of an ARX cipher against differential and impossible-differential cryptanalysis, the recent automated methods employ constraint satisfaction solvers to search for optimal characteristics or impossible differentials. The main difficulty in formulating this search is finding the differential models of the non-linear operations. While an efficient bit-vector differential model was obtained for the modular addition with two variable inputs, no differential model for the modular addition by a constant has been proposed so far, preventing ARX ciphers including this operation from being evaluated with automated methods. In this paper, we present the first bit-vector differential model for the n-bit modular addition by a constant input. Our model contains O ( log 2 ( n ) ) basic bit-vector constraints and describes the binary logarithm of the differential probability. We describe an SMT-based automated method that includes our model to search for differential characteristics of ARX ciphers including constant additions. We also introduce a new automated method for obtaining impossible differentials where we do not search over a small pre-defined set of differences, such as low-weight differences, but let the SMT solver search through the space of differences. Moreover, we implement both methods in our open-source tool ArxPy to find characteristics and impossible differentials of ARX ciphers with constant additions in a fully automated way. As some examples, we provide related-key impossible differentials and differential characteristics of TEA, XTEA, HIGHT, LEA, SHACAL-1, and SHACAL-2, which achieve better results compared to previous works.

Serum Oxytocin in Cows Is Positively Correlated with Caregiver Interactions in the Impossible Task Paradigm.

This study explored a possible relationship between the circulating oxytocin, cortisol, and the willingness of dairy cows to engage in social behaviors with humans in an experimental context. The behaviors of twenty-nine cows were recorded during the impossible task paradigm, a procedure aimed at creating a violation of expectancy, in the presence of the caregiver and a stranger. The results showed that serum oxytocin levels were positively correlated with duration and negatively correlated with the latency of the cows' social interactions with the caregiver. This research provides a clear correlation between circulating oxytocin and a willingness to engage in social contact with the caregiver, excluding the possible effect of different cortisol levels on such behavior.

Effects of a Nutritional Supplement (DìRelaxTM) on Anxiety in Dogs in a Randomized Control Trial Design.

This study aimed to investigate the efficacy of DìRelaxTM, a nutraceutical formulated to reduce anxiety in dogs, using a randomized controlled trial (RCT) design. The C-BARQ questionnaire, some clinical investigations, and the impossible task test were performed in dogs before and after treatment. The C-BARQ questionnaire is particularly useful for assessing the frequency and severity of problematic behaviors. The impossible task paradigm provides insight into the decision-making processes in the realm of expectancy frustration. Results showed an ameliorative effect on the performances of treated dogs during the solvable phases, with a significant decrease in the time needed to solve the task. No behavioral difference was found between treated and untreated anxious dogs during the unsolvable phase. According to the results from the C-BARQ questionnaire, some of the behaviors appeared to improve. Clinical investigations, including a complete blood cell count and blood chemistry, showed no difference between groups, thus suggesting the safety of the product. In general, this study suggests that DìRelaxTM can be safely administered with no adverse effects and can exercise a beneficial effect on anxious dogs by enhancing their cognitive abilities, but further studies should investigate the best method of administration.

Disentangling help-seeking and giving up: differential human-directed gazing by dogs in a modified unsolvable task paradigm.

Dogs are renowned for 'looking back' at humans when confronted with a problem, but it has been questioned whether this implies help-seeking or giving up. We tested 56 pet dogs from two breed groups (herding dogs and terriers) in a modified unsolvable task paradigm. One reward type (food or toy) was enclosed in a box, while the respective other reward was accessible. With both reward types, human-directed gazing in relation to the box was significantly positively correlated with interaction with the box, as long as an alternative was available. This suggests that both behaviours served to attain the unavailable reward and reflected individual motivation for the inaccessible vs the accessible reward. Furthermore, we varied whether the owner or the experimenter was responsible for handling the rewards. In the owner-responsible group, dogs rarely gazed at the experimenter. In the experimenter-responsible group, dogs preferentially directed box-related gazing (prior to or after looking at or interacting with the box) at the owner. Still, they gazed at the experimenter significantly longer than the owner-responsible group. Conversely, toy-related gazing was directed significantly more at the experimenter. Thus, dogs adjust their gazing behaviour according to the people's responsibility and their current goal (help-seeking vs play). Gaze duration did not differ between herding dogs and terriers. We conclude that dogs use gazing at humans' faces as a social problem-solving strategy, but not all gazing can be classified as such. Dogs' human-directed gazing is influenced by the social relationships with the persons, situational associations, and context (unsolvable problem vs play).

Psicanálise e utopia: Diálogos sobre abordagens divergentes / Psychoanalysis and utopia: Dialogues on divergent approaches / Psicoanálisis y utopía: Diálogos sobre enfoques divergentes

O presente artigo propõe uma revisão de literatura que objetiva mapear a relação entre psicanálise e utopia. Mais especificamente, que busca situar brevemente o que psicanalistas e autores que se utilizam da psicanálise versam sobre o tema da utopia no Brasil, sem a intenção de, com isso, fazer uma descrição exaustiva dessas diferentes abordagens do problema, mas assimilando-as à nossa maneira. Para tanto, foram compilados um total de onze ensaios, dos quais cinco são artigos publicados em periódicos acadêmicos e os outros seis são capítulos de livro. Os ensaios que compõem esta revisão se voltam para articulações conceituais da ideia de utopia que em alguma medida passem pela teorização psicanalítica, de modo que o foco está no conceito em si, e não nas diferentes manifestações de uma discursividade utópica. Destaca-se, das diferentes abordagens, a ambivalência que envolve a relação da psicanálise com a utopia, que a constitui um profícuo campo de diálogo e debate.

This article proposes a literature review that aims to map the relationship between psychoanalysis and utopia. More specifically, it seeks to briefly situate what psychoanalysts and authors who use psychoanalysis say about the theme of utopia in Brazil, without meaning to carry out an exhaustive description of these different approaches to the problem, but assimilating them in our own way. For this purpose, a total of eleven essays were compiled, of which five are articles published in academic journals and the other six are book chapters. The essays that make up this review focus on conceptual articulations of the idea of utopia that to some extent pass through psychoanalytic theorization, so that the focus is on the concept itself, and not on the different manifestations of a utopian discourse. The ambivalence surrounding the relationship between psychoanalysis and utopia stands out from the different approaches, which make it a rich field for dialogue and debate.

Este artículo propone una revisión de literatura que tiene como objetivo mapear la relación entre el psicoanálisis y la utopía. Más específicamente, busca ubicar brevemente lo que psicoanalistas y autores que usan el psicoanálisis tratan sobre el tema de la utopía en Brasil, sin la intención de hacer una descripción exhaustiva de estos diferentes enfoques del problema, pero asimilándolos a nuestra manera. Para ello, se recopilaron un total de once ensayos, los cuales cinco son artículos publicados en revistas académicas y los otros seis son capítulos de libro. Los ensayos que componen esta revisión se centran en las articulaciones conceptuales de la idea de utopía que, en cierta medida, pasan por la teorización psicoanalítica, de modo que el foco está en el concepto en sí mismo, y no en las diferentes manifestaciones de un discurso utópico. De los diferentes enfoques, se destaca la ambivalencia que implica la relación del psicoanálisis con la utopía, que la constituye como un campo fructífero de diálogo y debate.

Effect of different experiences with humans in dogs' visual communication.

Dogs are particularly skillful in communicating with humans, and growing evidence points towards the importance of both species intertwined evolutionary history and intense daily partnership. Gaze alternation is a communicative behavior used by dogs from a very young age and is affected by factors such as aging and experience. We analyzed how different degrees of daily human interaction affect dogs' gazing behavior in the unsolvable task, where a desired food becomes inaccessible. Three groups with different degrees of daily exposure to humans were compared: pet dogs that live inside the house, pet dogs that live outside the house, and shelter dogs. We found no difference in latency to the first gaze, but pet dogs did show a higher proportion of individuals engaging in gaze alternation, a higher number of gaze alternations, and a longer duration of gaze than shelter dogs. Additionally, dogs living inside the house gazed more at the experimenter than dogs living outside. Overall, our results indicate a strong influence of experience over the development and use of these communicative behaviors in dogs, with groups that are closer to people in their daily lives being more willing to communicate with humans as a strategy to obtain a desired goal.

Transforming Impossible into Possible (TIP) for SUD recovery: A promising practice innovation to combat the opioid crisis.

The purpose of this study is to examine the psychological self-sufficiency (PSS) process among low-income individuals participating in the Transforming Impossible into Possible (TIP) program and explore the implications of TIP as a SUD recovery intervention. A sample of 622 individuals from 9 local job training programs in a large Midwestern city was used to examine the group differences in substance abuse barrier and employment hope as they relates to economic self-sufficiency (ESS). Individuals in the TIP program (n = 315) had statistically significant path coefficients between substance abuse barriers, employment hope and ESS while the non-TIP counterpart (n = 307) showed a significant path only between employment hope and ESS. Also, the time difference score in substance abuse barrier and ESS was greater for the TIP group compared to the non-TIP comparison group. Results provide implications for social work practice among persons with SUDs. While the traditional employment programs focused only on the interview and job skills, TIP allowed participants to discover their resources to address the inner obstacles that have been holding them back. TIP could serve as a promising model to treat SUDs and support the recovery process.

"Impossible" Somatosensation and the (Ir)rationality of Perception.

Impossible figures represent the world in ways it cannot be. From the work of M. C. Escher to any popular perception textbook, such experiences show how some principles of mental processing can be so entrenched and inflexible as to produce absurd and even incoherent outcomes that could not occur in reality. However, impossible experiences of this sort are mostly limited to visual perception; are there "impossible figures" for other sensory modalities? Here, we import a known magic trick into the laboratory to report and investigate an impossible experience for somatosensation-one that can be physically felt. We show that, even under full-cue conditions with objects that can be freely inspected, subjects can be made to experience a single object alone as feeling heavier than a group of objects that includes the single object as a member-an impossible and phenomenologically striking experience of weight. Moreover, we suggest that this phenomenon-a special case of the size-weight illusion-reflects a kind of "anti-Bayesian" perceptual updating that amplifies a challenge to rational models of perception and cognition.

The distinct and overlapping brain networks supporting semantic and spatial constructive scene processing.

Scene imagery features prominently when we recall autobiographical memories, imagine the future and navigate around in the world. Consequently, in this study we sought to better understand how scene representations are supported by the brain. Processing scenes involves a variety of cognitive processes that in the real world are highly interactive. Here, however, our goal was to separate semantic and spatial constructive scene processes in order to identify the brain areas that were distinct to each process, those they had in common, and the connectivity between regions. To this end, participants searched for either semantic or spatial constructive impossibilities in scenes during functional MRI. We focussed our analyses on only those scenes that were possible, thus removing any error detection that would evoke reactions such as surprise or novelty. Importantly, we also counterbalanced possible scenes across participants, enabling us to examine brain activity and connectivity for the same possible scene images under two different conditions. We found that participants adopted different cognitive strategies, which were reflected in distinct oculomotor behaviour, for each condition. These were in turn associated with increased engagement of lateral temporal and parietal cortices for semantic scene processing, the hippocampus for spatial constructive scene processing, and increased activation of the ventromedial prefrontal cortex (vmPFC) that was common to both. Connectivity analyses showed that the vmPFC switched between semantic and spatial constructive brain networks depending on the task at hand. These findings further highlight the well-known semantic functions of lateral temporal areas, while providing additional support for the previously-asserted contribution of the hippocampus to scene construction, and recent suggestions that the vmPFC may play a key role in orchestrating scene processing.

Deep memory distortions.

Deep distortions are a new family of memory biases that comprise one of the two basic varieties of false memory. The first and older variety, surface distortions, are specific item or source memories that are erroneous because the events did not happen. The new variety, deep distortions, are emergent properties of multiple specific memories. They are relations among such memories that are false because they violate objective logical rules that real-world events must obey. I discuss four deep distortions for which substantial data have accumulated: overdistribution, super-overdistribution, non-additivity, and impossible conjunctions. These phenomena violate four axioms of classical probability (numerical bound, universal event, additivity, and countable additivity) and two rules that follow from them (empty set and monotonicity). Their psychological significance lies in four facts about them: (a) They demonstrate that although events in the real world are compensatory, our memories of them are not; (b) they establish that we persistently over remember experience; (c) they reveal that surface distortions are by-products of deep distortions; and (d) they pose the theoretical conundrum of how the structure of memory could so thoroughly misrepresent the objective structure of the events we are remembering.